The crash was reported at 5:37 p.m. at Gallatin Road and Rosemead Boulevard, according to the California Highway Patrol.
The crash scene was described as involving a white Subaru, black Jeep, blue Nissan sedan, a black Ford sedan and an unknown vehicle.
Los Angeles County firefighters responded to the scene, said Dispatch Supervisor Jeremy Stafford.
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An arriving officer reported that paramedics started chest compressions on a person, and that the coroner was requested at 6:28 p.m. after the man was pronounced dead at the scene.