According to the LA County Fire Department, the crash was reported just before 10 a.m. in the area near Gallatin Road and Rosemead Boulevard.
Officials said the two deputies were responding to a robbery in progress when they crashed with another car. The two incidents were not related.
The deputies' patrol car was one of four vehicles involved in the crash.
The deputies sustained significant but non-life-threatening injuries, authorities said. No civilians were injured.
The intersection was closed off as officials investigated.