The crash happened at 2200 S. Sawtelle Blvd. and was reported at 2:58 p.m., according to Los Angeles Fire Department spokeswoman Margaret Stewart.
A 79-year-old woman suffered the worst injuries and was transported to a hospital in critical condition. Two women, 20 and 23, were taken to the hospital with serious injuries, Stewart said.
A 70-year-old man, a 26-year-old woman and a 26-year-old man all suffered non-life-threatening injuries and were hospitalized, she said.
The crash was being investigated by the Los Angeles police, she said.