The vehicle crashed about 11 a.m. near 29th Street and Vineyard Avenue, according to the Los Angeles Police Department.
Officers began searching for the suspect, an effort that was continuing early Friday afternoon.
A short time before the suspect crashed, an LAPD vehicle crashed near Jefferson Boulevard and Farmdale Avenue, according to police.
Two people were transported from that area for hospital treatment in unknown condition, according to the Los Angeles Fire Department.
No officers sustained any injuries, according to an LAPD spokeswoman.