According to California Highway Patrol, officers responded to the southbound 405 Freeway at North Mulholland Drive around 4:42 a.m.
That's where they found the two vehicles - a semi-truck and a Volkswagen Beetle - on the side of the freeway with substantial damage.
The truck was being driven at a "low speed" when the car crashed into it and became lodged underneath it, according to the CHP.
The driver of the Volkswagen died at the scene.
It was not immediately known if drugs or alcohol were factors in the crash, the CHP reported.
Two lanes on the southbound 405 Freeway were closed for hours while CHP investigated the crash.
All lanes reopened just after 11 a.m.