Firefighters responded to the scene around 9 p.m. Sunday near the intersection of Vanowen Street and Corbin Avenue.
When firefighters arrived they determined three people had been ejected from a Ford Explorer. They were all pronounced dead at the scene.
The Los Angeles County Coroner's Office identified the victims as Steve Orellana Jr., 22, of Reseda, Celestino Fuentes, 22, of Burbank, and Isaiah Sanchez, 23, of Northridge.
Investigators with the Los Angeles Police Department said the driver of the SUV was going nearly twice the speed limit of 35 mph when he lost control and slammed into oncoming traffic. At least three cars were involved in the crash.
"This is a huge reminder to all of us that speed, particularly on residential streets in the Valley is really dangerous," LAPD Capt. Andrew Neiman said.
Six others sustained "potentially serious" injuries, but were stable upon being transported to the hospital, according to officials.
There was no other information immediately available.