It happened at the intersection of Venice Blvd. and S. Cochran Ave. around 9 a.m., according to the Los Angeles Fire Department.
Both the officer in the patrol vehicle and the civilian involved are out of their vehicles and speaking with authorities.
One person was transported for hospital treatment in unknown condition.
Venice Blvd. was closed between Redondo and Hauser for the investigation but all roads have since reopened.
The cause of the crash is not yet known.
City News Service contributed to this report.