The sedan wound up on top of a home in the 500 block of Palos Verdes Drive West around 3:40 p.m., authorities said.
According to Capt. Mark Velez of the Palos Verdes Estate Police Department, the motorist began suffering some type of medical problem while driving. He veered to the right and into a yard, where he struck a parked car.
The man's car was launched into the air, landing atop the tile roof, Velez said.
The man was taken to a hospital, primarily for the prior medical problem rather than any injuries suffered in the crash.
A crane was brought in to remove the car from the roof.