A 68-year-old driver in the third vehicle suffered minor injuries, as did the 20-year-old man driving the pickup and his 18-year-old woman, said Margaret Stewart of the Los Angeles Fire Department.
She said the pickup was being pursued by another vehicle, but it was not clear if that was a police chase or some other circumstance.
Firefighters and paramedics were dispatched to the crash in the 10500 block of Victory Boulevard at 10:28 a.m., Stewart said. That is at an S-curve on Victory, just west of the Burbank city limit.
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